Harpavit
Supportive treatment of degenerative disorders of the musculoskeletal system.
Contains a well-proven medical plant that has been traditionally used for decades to treat chronic low back and joint pain.
Over-the counter medicine.
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Devil’s Claw is a well-established and traditionally used medicinal herb listed in major herbal pharmacopeias
European Community Herbal Monograph (EMEA / HMPC)
European Scientific Cooperative on Phytotherapy (ESCOP)
German Commission E monograph (BGA)
German Homeopathic Pharmacopoeia (HAB 34)
British Herbal Pharmacopoeia (BP)
Pharmacopée Française
Health Canada : Natural Health Product Ingredient DB‧
US Pharmacopeial Conventions : Herbal Medicines Compendium
Drug
Devil’s claw, als known as Harpagophytum, is an important traditional medicine growing in the Kalahari region of southern Africa where it is consumed as a general health tonic and for treating diverse ailments including joint pain.
Harpavit - Optimal approach against symptomatic degenerative joint disease.1,2
- Relieves osteoarthritis and slows down the damage of cartilage tissue.1,2
- Relieves low back pain.1,2
- Relieves osteoarthritis-related joint pain, swelling and inflammation.1,2
- Maintains healthy cartilage and bone, and contribute to mature bone.1,2
Pharmacological effects:
Four main biological activities of Devil’s claw root for the treatment of joint disease.3, 4, 5
Analgesic effects
Proven in various thermally, chemically and mechanically induced in vivo pain tests in rats.
Anti-inflammatory effects
Demonstrated by numerous in vivo investigations: Inhibiting of cytokines (IL-1β, IL-6 and TNF-α) involved in the pathogenesis of degenerative joint disease and immune modulation.
Chondroprotective effects
Inhibition of matrix metalloproteinases and elastase.
Antioxidative effects
Inhibiting the release of reactive oxygen specifically damaging membrane lipids, proteins and DNA and RNA.
Mandatory Information
Harpavit film-coated tablets
1 film-coated tablet contains:
Active ingredient: Dry extract of Devil’s claw root (1.5-2.5:1); extraction solvent: water, 600 mg
Area of application:
Supportive treatment of degenerative disorders of the musculoskeletal system in adults.
Contains Lactose and Sucrose (sugars).
For risks and side effects, please ask your doctor and pharmacist.
References:
1 Menghini L, Recinella L, Leone S, et al. Devis´s claw (Harpagoyphtum procumbens) and inflammatory diseases; A concise overview on preclinical and clinical data. Phytother Res.2019 Jul 4, doi: 10.1002/ptr.6395.
2 Brien S, Lewith GT, McGregor G. J Altern Complement Med. 2006 Dec; 12(10): 981-93.
3 HARPAVIT study. Effects of a Devil´s claw root dry extract (Harpagophytum procumbens, radix) on the viability and on the LPS induced IL-1ß, IL-6, IL-8 and TNF-α release in periperal human monocytes. Vivacell Biotechnology. Commissioned by Evers: Appel K. 2012.
4 Dragos D, et al. Phytomedicine in Joint Disorders. Nutrients 2017; 9(1):70
5 Jang MH, et al. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci, 2003; 93: 367-371
