eviprostat®-S

sabal serrulatum 320mg UNO

The active components from the fruit of saw palmetto relieve the urinary symptoms caused by benign prostatic enlargement

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Herbal approach to improve urinating complaints due to benign prostatic hyperplasia (BPH).

  • Well-tolerated herbal product ameliorates the typical urinary symptoms caused by BPH.
  • Reduces swelling and inflammation of the prostate tissue.
  • Effectively reduces the urge to urinate, improves difficult urination and strengthens the urinary stream.
  • Improves urinary parameters such as flow rates and residual volume.

Principle outcomes of clinical studies of Saw palmetto fruit extracts:

  • Saw palmetto provides improvement in urinary symptoms in mild to moderate BPH based on standardised endpoints (IPSS).
  • Saw palmetto provides moderate improvement of uroflowmetry parameters and decreases nocturia without increasing serum Prostate-specific antigen (PSA).
  • Saw palmetto was reported to be possibly equivalent to the 5 α-reductase inhibitor finasteride (with fewer side effects).
  • Saw palmetto was reported to be possibly equivalent to the α-blocking agent tamsulosin (with fewer side effects).

Several experimental finding (in vitro and in vivo) support the plausibility of use of Saw palmetto fruit extract in BPH.

Anti-androgenic effects

Inhibition of a receptor binding

Anti-proliferative effect

Anti-spasmolytic effect

Anti-inflammatory effect

Anti-androgenic effects

  • Inhibition of the activity of 5 α-reductase, an enzyme converting testosterone into the active compound DHT, in prostatic epithelium and stroma.
  • Inhibition of prostatic growth in athymic nude mice, in which human benign hyperplastic prostatic tissue had been transplanted.

Inhibition of a receptor binding

  • Inhibition of tamsulosin binding to human α1 adrenoceptors (non competitive).

Anti-proliferative effect

  •  Significant inhibition of proliferation and introduction of cell death in human BPH tissue from patients (both epithelium and stroma).
  • Reduction of weight of the prostate in castrated rats and mice treated with testosterone.

Anti-spasmolytic effect

  • Relaxing tonic contractions induced by vanadate, noradrenalin etc. in various smooth muscle preparations.
  • Inhibition of calmodulin-dependent cAMP phosphodiesterse activity.

Anti-inflammatory effect

  • Inhibiting the production of leukotriene B4.
  • Suppressing the calcium ionophore-stimulated synthesis of thromboxane B2.

Mandatory Information

Eviprostat-S sabal serrulatum 320mg UNO

Area of application:

For improvement of prostate-dependent disorders during urination due to benign enlargement of the prostate (micturition disorders due to benign prostate hyperplasia stadium I to II acc. to Alken resp. II to III acc. to Vahlensieck).

For risks and side effects, please ask your doctor or pharmacist