Eviprostat®-S 320mg UNO
The active components from the fruit of saw palmetto relieve the urinary symptoms caused by benign prostatic enlargement.
Eviprostat-S sabal serrulatum 320mg UNO
Area of application:
For improvement of prostate-dependent disorders during urination due to benign enlargement of the prostate (micturition disorders due to benign prostate hyperplasia stadium I to II acc. to Alken resp. II to III acc. to Vahlensieck).
For risks and side effects, please ask your doctor or pharmacist
Herbal approach to improve urinating complaints due to benign prostatic hyperplasia (BPH).
Principle outcomes of clinical studies of Saw palmetto fruit extracts:
Saw palmetto provides improvement in urinary symptoms in mild to moderate BPH based on standardised endpoints (IPSS).
Saw palmetto provides moderate improvement of uroflowmetry parameters and decreases nocturia without increasing serum Prostate-specific antigen (PSA).
Saw palmetto was reported to be possibly equivalent to the 5 α-reductase inhibitor finasteride (with fewer side effects).
Saw palmetto was reported to be possibly equivalent to the α-blocking agent tamsulosin (with fewer side effects).
Several experimental finding (in vitro and in vivo) support the plausibility of use of Saw palmetto fruit extract in BPH.
|Pharmacological Effect||Mechanism of Action|
|Anti-androgenic effects||• Inhibition of the activity of 5 α-reductase, an enzyme converting testosterone into the active compound DHT, in prostatic epithelium and stroma.|
• Inhibition of prostatic growth in athymic nude mice, in which human benign hyperplastic prostatic tissue had been transplanted.
|Inhibition of a receptor binding||• Inhibition of tamsulosin binding to human α1 adrenoceptors (non competitive).|
|Anti-proliferative effect||• Significant inhibition of proliferation and introduction of cell death in human BPH tissue from patients (both epithelium and stroma).|
• Reduction of weight of the prostate in castrated rats and mice treated with testosterone.
|Anti-spasmolytic effect||• Relaxing tonic contractions induced by vanadate, noradrenalin etc. in various smooth muscle preparations.|
• Inhibition of calmodulin-dependent cAMP phosphodiesterse activity.
|Anti-inflammatory effect||• Inhibiting the production of leukotriene B4.|
• Suppressing the calcium ionophore-stimulated synthesis of thromboxane B2.